To study the influence of several constraints on mutational tolerance throughout choice, we selected E. coli dihydrofolate reductase (DHFR) as being a model method. DHFR is an essential enzyme within folate metabolism that cuts down dihydrofolate to tetrahydrofolate and is essential for thymidine manufacturing. making use of this activity as The premise for an in vivo assortment assay (Reynolds et al., 2011), we aimed initially to evaluate a mutational landscape for DHFR after which you can to ascertain how a improve into the cellular environment might impact the landscape. Because DHFR is thought to progress through various conformational states through catalysis (Boehr et al.
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